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1

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A

Tietjen, Ian, Williams, David E., Read, Silven, Kuang, Xiaomei T., Mwimanzi, Philip, Wilhelm, Emmanuelle, Markle, Tristan, Kinloch, Natalie N., Naphen, Cassandra N., Tenney, Karen, Mesplède, Thibault,

Journal:

Antiviral Research

Year:

2018

Language:

english

File:

PDF, 1.93 MB

english, 2018

2

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

Mesplède, Thibault, Wainberg, Mark

Journal:

Year:

2015

Language:

english

File:

PDF, 346 KB

english, 2015

3

What if HIV were unable to develop resistance against a new therapeutic agent?

Wainberg, Mark A, Mesplède, Thibault, Raffi, Francois

Journal:

Year:

2013

Language:

english

File:

PDF, 322 KB

english, 2013

4

Fitness Impaired Drug Resistant HIV-1 Is Not Compromised in Cell-to-Cell Transmission or Establishment of and Reactivation from Latency

Bastarache, Sophie, Mesplède, Thibault, Donahue, Daniel, Sloan, Richard, Wainberg, Mark

Journal:

Year:

2014

Language:

english

File:

PDF, 756 KB

english, 2014

5

Is Resistance to Dolutegravir Possible When This Drug Is Used in First-Line Therapy?

Mesplède, Thibault, Wainberg, Mark

Journal:

Year:

2014

Language:

english

File:

PDF, 718 KB

english, 2014

6

Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay

Han, Ying-Shan, Penthala, Narsimha Reddy, Oliveira, Maureen, Mesplède, Thibault, Xu, Hongtao, Quan, Yudong, Crooks, Peter A., Wainberg, Mark A.

Journal:

Journal of Medical Virology

Year:

2016

Language:

english

File:

PDF, 466 KB

english, 2016

7

Investigational HIV integrase inhibitors in phase I and phase II clinical trials

Han, Yingshan, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Expert Opinion on Investigational Drugs

Year:

2017

Language:

english

File:

PDF, 881 KB

english, 2017

8

Where are we with injectables against HIV infection and what are the remaining challenges?”

Hassounah, Said A., Mesplède, Thibault

Journal:

Expert Review of Anti-infective Therapy

Year:

2018

Language:

english

File:

PDF, 940 KB

english, 2018

9

HIV-1 resistance dynamics in patients failing dolutegravir maintenance monotherapy

Wijting, Ingeborg E A, Lungu, Cynthia, Rijnders, Bart J A, van der Ende, Marchina E, Pham, Hanh T, Mesplede, Thibault, Pas, Suzan D, Voermans, Jolanda J C, Schuurman, Rob, van de Vijver, David A M C,

Journal:

The Journal of Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 825 KB

english, 2018

10

Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

Oliveira, Maureen, Ibanescu, Ruxandra-Ilinca, Anstett, Kaitlin, Mésplède, Thibault, Routy, Jean-Pierre, Robbins, Marjorie A., Brenner, Bluma G.

Journal:

Year:

2018

Language:

english

File:

PDF, 911 KB

english, 2018

11

Lamivudine-resistant HIVM184V is Durably Suppressed with Dolutegravir plus Lamivudine Dual Therapy in Humanized Mice

Medina-Moreno, Sandra, Zapata, Juan C., Kashanchi, Fatah, Le, Nhut M., Hassounah, Said, Mesplede, Thibault, Oliveira, Maureen, Davis, Charles C., Heredia, Alonso

Journal:

Journal of Global Antimicrobial Resistance

Year:

2020

Language:

english

File:

PDF, 703 KB

english, 2020

12

Involvement of TBK1 and IKKϵ in lipopolysaccharide-induced activation of the interferon response in primary human macrophages

Mayra Solis, Raphaëlle Romieu-Mourez, Delphine Goubau, Nathalie Grandvaux, Thibault Mesplede, Ilkka Julkunen, Alessandra Nardin, Margarita Salcedo, John Hiscott

Journal:

European Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 403 KB

english, 2007

13

Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7

Delphine Goubau, Raphaëlle Romieu-Mourez, Mayra Solis, Eduardo Hernandez, Thibault Mesplède, Rongtuan Lin, Douglas Leaman, John Hiscott

Journal:

European Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 660 KB

english, 2009

14

A high-throughput assay for HIV-1 integrase 3′-processing activity using time-resolved fluorescence

Ying-Shan Han, Peter Quashie, Thibault Mesplede, Hongtao Xu, Kevork Mekhssian, Craig Fenwick, Mark A. Wainberg

Journal:

Journal of Virological Methods

Year:

2012

Language:

english

File:

PDF, 702 KB

english, 2012

15

10 X-linked inhibitor of apoptosis protein inhibits RIG-I signalling pathway

Peyman Nakhaei, Thibault Mesplède, Qiang Sun, Simon Leveillé, Robert G. Korneluk, John Hiscott

Journal:

Year:

2008

Language:

english

File:

PDF, 47 KB

english, 2008

16

355 Triad3A E3 ligase negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

Peyman Nakhaei, Thibault Mesplede, Qiang Sun, Mayra Solis, Long Yang, Rongtuan Lin, Tsung-Hsien Chuang, Carl F. Ware, John Hiscott

Journal:

Year:

2008

Language:

english

File:

PDF, 44 KB

english, 2008

17

261 Activation of TLR-independent signaling pathway by HIV-1 in primary human macrophages

Mayra Solis, Thibault Mesplede, Peyman Nakhaei, John Hiscott

Journal:

Year:

2008

Language:

english

File:

PDF, 40 KB

english, 2008

18

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

Peyman Nakhaei, Thibault Mesplede, Mayra Solis, Qiang Sun, Tiejun Zhao, Long Yang, Tsung-Hsien Chuang, Carl F. Ware, Rongtuan Lin, John Hiscott

Journal:

Year:

2009

Language:

english

File:

PDF, 61 KB

english, 2009

19

The development of novel HIV integrase inhibitors and the problem of drug resistance

Mark A Wainberg, Thibault Mesplède, Peter K Quashie

Journal:

Current Opinion in Virology

Year:

2012

Language:

english

File:

PDF, 307 KB

english, 2012

20

HIV Drug Resistance and the Advent of Integrase Inhibitors

Quashie, Peter K., Mesplède, Thibault, Wainberg, Mark A.

Journal:

Current Infectious Disease Reports

Year:

2013

Language:

english

File:

PDF, 440 KB

english, 2013

21

Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors

Han, Ying-Shan, Xiao, Wei-Lie, Quashie, Peter K., Mesplède, Thibault, Xu, Hongtao, Deprez, Eric, Delelis, Olivier, Pu, Jian-Xin, Sun, Han-Dong, Wainberg, Mark A.

Journal:

Antiviral Research

Year:

2013

Language:

english

File:

PDF, 705 KB

english, 2013

22

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

Thibault Mesplède, Peter K Quashie, Nathan Osman, Yingshan Han…

Journal:

Year:

2013

Language:

english

File:

PDF, 360 KB

english, 2013

23

The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

Wares, Melissa, Mesplède, Thibault, Quashie, Peter K, Osman, Nathan, Han, Yingshan, Wainberg, Mark A

Journal:

Year:

2014

Language:

english

File:

PDF, 249 KB

english, 2014

24

Integrase Strand Transfer Inhibitors in HIV Therapy

Mesplède, Thibault, Wainberg, Mark A.

Journal:

Infectious Diseases and Therapy

Year:

2013

Language:

english

File:

PDF, 362 KB

english, 2013

25

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity

Singhroy, Diane N, Mesplède, Thibault, Sabbah, Arielle, Quashie, Peter K, Falgueyret, Jean-Pierre, Wainberg, Mark A

Journal:

Year:

2013

Language:

english

File:

PDF, 456 KB

english, 2013

26

Integrase strand transfer inhibitors in the management of HIV-positive individuals

Mesplède, Thibault, Quashie, Peter K., Zanichelli, Veronica, Wainberg, Mark A.

Journal:

Annals of Medicine

Year:

2014

Language:

english

File:

PDF, 218 KB

english, 2014

27

Differential Effects of the G118R, H51Y, and E138K Resistance Substitutions in Different Subtypes of HIV Integrase

Quashie, Peter K., Oliviera, Maureen, Veres, Tamar, Osman, Nathan, Han, Ying-Shan, Hassounah, Said, Lie, Yolanda, Huang, Wei, Mesplède, Thibault, Wainberg, Mark A., Doms, R. W.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

28

Combination of the R263K and M184I/V Resistance Substitutions against Dolutegravir and Lamivudine Decreases HIV Replicative Capacity

Singhroy, Diane N., Wainberg, Mark A., Mesplède, Thibault

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

29

Dolutegravir Resistance Mutation R263K Cannot Coexist in Combination with Many Classical Integrase Inhibitor Resistance Substitutions

Anstett, Kaitlin, Mesplede, Thibault, Oliveira, Maureen, Cutillas, Vincent, Wainberg, Mark A., Ross, S. R.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 474 KB

english, 2015

30

The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir

Cutillas, Vincent, Mesplede, Thibault, Anstett, Kaitlin, Hassounah, Said, Wainberg, Mark A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

31

Dolutegravir inhibits HIV-1 Env evolution in primary human cells

Mesplède, Thibault, Moïsi, Daniela, Oliveira, Maureen, Ibanescu, Ilinca, Ohnona, Frédéric, Brenner, Bluma, Wainberg, Mark A.

Journal:

Year:

2015

Language:

english

File:

PDF, 300 KB

english, 2015

32

Resistance to HIV integrase inhibitors

Mesplède, Thibault, Quashie, Peter K., Wainberg, Mark A.

Journal:

Current Opinion in HIV and AIDS

Year:

2012

Language:

english

File:

PDF, 391 KB

english, 2012

33

Simian-Tropic HIV as a Model To Study Drug Resistance against Integrase Inhibitors

Wares, Melissa, Hassounah, Said, Mesplède, Thibault, Sandstrom, Paul A., Wainberg, Mark A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 936 KB

english, 2015

34

Evolution of HIV integrase resistance mutations

Quashie, Peter K., Mesplède, Thibault, Wainberg, Mark A.

Journal:

Current Opinion in Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 275 KB

english, 2012

35

Exposure to Entry Inhibitors Alters HIV Infectiousness and Sensitivity to Broadly Neutralizing Monoclonal Antibodies

Kramer, Victor G., Varsaneux, Olivia, Oliviera, Maureen, Colby-Germinario, Susan P., Mesplède, Thibault, Wainberg, Mark A.

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2014

Language:

english

File:

PDF, 572 KB

english, 2014

36

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

Nakhaei, Peyman, Mesplede, Thibault, Solis, Mayra, Sun, Qiang, Zhao, Tiejun, Yang, Long, Chuang, Tsung-Hsien, Ware, Carl F., Lin, Rongtuan, Hiscott, John, Gale, Michael

Journal:

Year:

2009

Language:

english

File:

PDF, 799 KB

english, 2009

37

Positive and Negative Control of Virus-induced Interferon-A Gene Expression

Mesplède, Thibault, Navarro, Sébastien, Génin, Pierre, Morin, Pierre, Island, Marie-Laure, Bonnefoy, Eliette, Civas, Ahmet

Journal:

Year:

2003

Language:

english

File:

PDF, 143 KB

english, 2003

38

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

Osman, Nathan, Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Zanichelli, Veronica, Wainberg, Mark A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2015

Language:

english

File:

PDF, 318 KB

english, 2015

39

The combination of the R263K and T66I resistance substitutions in HIV-1 integrase is incompatible with high level viral replication and the development of high-level drug resistance

Liang, Jiaming, Mesplède, Thibault, Oliveira, Maureen, Anstett, Kaitlin, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 1.83 MB

english, 2015

40

Dolutegravir-selected HIV-1 containing the N155H/R263K resistance substitutions does not acquire additional compensatory mutations under drug pressure that lead to higher level resistance and increased replicative capacity

Anstett, Kaitlin, Fusco, Robert, Cutillas, Vincent, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 621 KB

english, 2015

41

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in SIVmac239

Hassounah, Said A., Liu, Yannan, Quashie, Peter K., Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma G., Sandstrom, Paul A, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

42

Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity

Anstett, Kaitlin, Cutillas, Vincent, Fusco, Robert, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 278 KB

english, 2016

43

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

Brenner, Bluma G., Thomas, Réjean, Blanco, José Luis, Ibanescu, Ruxandra-Ilinca, Oliveira, Maureen, Mesplède, Thibault, Golubkov, Olga, Roger, Michel, Garcia, Federico, Martinez, Esteban, Wainberg, Ma

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 213 KB

english, 2016

44

Might dolutegravir be part of a functional cure for HIV? 1

Wainberg, Mark A., Han, Ying-Shan, Mesplède, Thibault

Journal:

Canadian Journal of Microbiology

Year:

2016

Language:

english

File:

PDF, 747 KB

english, 2016

45

Will LEDGIN molecules be able to play a role in a cure for HIV infection?

Mesplède, Thibault, Wainberg, Mark A.

Journal:

Year:

2016

Language:

english

File:

PDF, 611 KB

english, 2016

46

Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

Pham, Hanh T., Mesplède, Thibault, Wainberg, Mark A.

Journal:

Year:

2016

Language:

english

File:

PDF, 951 KB

english, 2016

47

HIV-1 Group O Resistance Against Integrase Inhibitors

Depatureaux, Agnès, Mesplède, Thibault, Quashie, Peter, Oliveira, Maureen, Moisi, Daniela, Plantier, Jean-Christophe, Brenner, Bluma, Wainberg, Mark A.

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2015

Language:

english

File:

PDF, 413 KB

english, 2015

48

Differences among HIV-1 subtypes indrug resistance against integrase inhibitors

Han, Ying-Shan, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Infection, Genetics and Evolution

Year:

2016

Language:

english

File:

PDF, 340 KB

english, 2016

49

A resveratrol analog termed 3,3′,4,4′,5,5′-hexahydroxy- trans -stilbene is a potent HIV-1 inhibitor

Han, Ying-Shan, Quashie, Peter K., Mesplède, Thibault, Xu, Hongtao, Quan, Yudong, Jaeger, Walter, Szekeres, Thomas, Wainberg, Mark A.

Journal:

Journal of Medical Virology

Year:

2015

Language:

english

File:

PDF, 144 KB

english, 2015

50

Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors

Oliveira, Maureen, Mesplède, Thibault, Quashie, Peter K., Moïsi, Daniela, Wainberg, Mark A.

Journal:

Year:

2014

Language:

english

File:

PDF, 398 KB

english, 2014

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